Introducing the Organic Multi-Mushroom Immunity Blend

With cold and flu season about to kick off, our immune systems need all the help they can get! We’ve launched our brand-new Organic Mushroom Immunity Blend just in time, with not one, not two, but FIVE immune-boosting mushroom extracts in one: 

  • Shiitake mushroom. One of the most popular types of mushroom, shiitake has been used in Eastern cuisine and medicine for centuries and is believed to increase longevity.[1]
  • Maitake mushroom. Japanese for ‘dancing mushroom’, maitake earned its name because people were said to dance with happiness thanks to its healing properties. 
  • Chaga mushroom. This cold-weather mushroom resembles a clump of mud but has a distinctive orange centre packed with beneficial compounds. 
  • Reishi mushroom. Reishi is a tropical fungus known as the “ancient mushroom of immortality” in its native Asia.[2][3]
  • Lion’s Mane mushroom. This striking mushroom gets its name from the cascades of strands that hang off it, and is also known for its cognitive and digestive benefits. 

The Organic Mushroom Immunity Blend also contains some superstar supporting ingredients that not only enhance the benefits, but pack some pretty amazing rewards of their own. 

  • Astragalus root is a fundamental herb in Chinese medicine, most commonly used for gut health.
  • Black pepper is known as the King of Spices in Ayurvedic medicine. [4][5] A potent ingredient in its own right, it also increases the absorption of other beneficial organic supplements like turmeric by as much as 2000%.[6]

How can the Organic Mushroom Blend support your immune system?

Studies look very promising so far and suggest that the blend can work alongside a healthy diet and an active lifestyle to support immunity. Here’s how…

The polysaccharide compounds in shiitake may improve immune strength,[7] rejuvenate immune cells,[8] and even slow or reverse the normal age-related decline of your immune system.[9] 

Lion’s Mane also contains beneficial polysaccharides that may stimulate activity in your intestinal immune system,[10][11] and it supports the healthy gut bacteria necessary to produce key disease-fighting cells.[12]

Both chaga and reishi mushrooms have been shown to stimulate creation of white blood cells and key immune proteins,[13][14][15][16][17] which may help you to fight off infection. Reishi is even thought to alter genetic pathways in white blood cells[18] and trigger the body’s ‘natural killer cells’.[19][20]

Supporting the immune power of the mushrooms, astragalus root may also promote healing and restoration of the immune system via the production of key cells.[21][22]

What else can it do?

May fight inflammation and oxidative stress

Inflammation is a normal immune response, but when it becomes chronic, it can cause serious health problems. It’s thought to be linked to everything from cardiovascular disease and dementia to diabetes and premature ageing.[23][24][25]  

Excessive inflammation can be caused by oxidative stress, which is when you don’t have enough antioxidants in your body to fight damaging chemicals called free radicals. The high antioxidant content of mushrooms may be able to help. 

Lion’s Mane mushroom, for example, is a potent source of antioxidants and has been shown to reduce oxidative stress, inflammation, and chronic illness risk.[26][27][28][29] The immune system’s ‘natural killer cells’, stimulated by reishi mushrooms, can also fight inflammation, [19][20] while chaga and shiitake appear to block the release of harmful inflammatory proteins.[13][8][30][31]

When it comes to inflammation, the real star player in the Organic Mushroom Blend is black pepper. Piperine, the main active compound, is an incredibly powerful antioxidant[32] shown to reduce free radical damage,[33][34] possibly protect against chronic disease,[35] and relieve everything from joint swelling[35][36] to respiratory irritation.[37][38]

May improve heart health

High LDL (“bad”) cholesterol and triglycerides are major risk factors for heart disease, while high HDL (“good”) cholesterol has a protective effect on the heart. 

Shiitake, chaga, Lion’s Mane, maitake and black pepper have all been shown to lower LDL and triglycerides and increase HDL, suggesting that they can help to support a healthy heart and protect against cardiovascular disease.[1][39][40][41][42][43][44][45][46][347][48][49][50]

Shiitake is also believed to have a positive effect on blood pressure,[1][51] another risk factor in heart disease, and it helps to reduce fatty build-up in the liver.[52] Both shiitake and Lion’s Mane may prevent fatty deposits on the artery walls,[52][53]  and Lion’s Mane has an anti-clotting effect on the blood,[54] all of which can reduce the risk of heart attack and stroke. 

May regulate blood sugar and protect against diabetes

Diabetes is one of the fastest-growing chronic diseases in the world, with terrible complications like blindness, organ failure, loss of limbs and premature death. Managing your blood sugar levels and keeping inflammation to a minimum is key to preventing diabetes, and research shows that certain types of mushrooms may help. 

Both maitake and chaga mushrooms have been shown to lower blood glucose levels in animal studies,[43][44][55][56][57][58] while Lion’s Mane may keep blood glucose stable by blocking the function of an enzyme that breaks down carbs.[59][60][61][62]

Finally, black pepper is thought to improve glucose metabolism,[63][64][65] restore proper insulin function,[66] and keep blood sugar spikes at bay.[67]

May support a healthy digestive system

If your digestive system is in distress, the rest of your body will be, too. That includes your immune system, which we now know is heavily influenced by the microbiota (friendly bacteria) throughout your digestive tract. 

Research shows that Lion’s Mane is particularly promising in maintaining a healthy gut. You can read more about the science-based benefits here , but to summarise, Lion’s Mane may: 

  • Prevent the growth of a bacteria that causes stomach ulcers.[68][69][70][71]
  • Protect against alcohol- or drug-induced stomach ulcers.[72]
  • Reduce tissue damage from disorders like colitis or inflammatory bowel disease.[73][74][75][76]

Astragalus has also been shown to have a positive effect on gut health. It may:

  • Improve absorption of amino acids, peptides, fatty acids and vitamins.[77][78]
  • Repair ulcerated and damaged intestinal tissue.[77]
  • Reduce inflammation in the digestive tract.[77] 
  • Restore microbiota function.[79] 

These are just a few of the benefits of these magical medicinal mushrooms, and with the Organic Mushroom Blend, you can get them all in one place. 

Is the Organic Mushroom Blend safe?

The available research says that yes, the ingredients are safe for most people.

That said, if you have liver or kidney problems, it’s best to be on the safe side and avoid the Organic Mushroom Blend. Pregnant or breastfeeding women and people with blood disorders or low blood pressure should also steer clear.[82]

Due to the immune-boosting properties of the ingredients, you should avoid Organic Mushroom Blend if you’re undergoing immune therapy (e.g. for transplant, HIV, autoimmune disorders, etc.) as it may interfere with your treatment. 

If you have any concerns, or you experience any worrying side effects, see your doctor. 

Get your Organic Mushroom Immunity Blend in time for winter

Give your immune system a boost this winter with five powerful medicinal mushrooms, all in one convenient capsule. Buy it now at Feel Supreme.




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2 Ganoderma lucidum (Lingzhi or Reishi)

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3 Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer.

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4 Black pepper and health claims: a comprehensive treatise.

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5 A Review on Therapeutic Potential of Piper nigrum L. (Black Pepper): The King of Spices

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6 Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials 

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7 Lentinula edodes-derived polysaccharide enhances systemic and mucosal immunity by spatial modulation of intestinal gene expression in mice.

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8 Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.

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9 Lentinula edodes-derived polysaccharide rejuvenates mice in terms of immune responses and gut microbiota.

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10 Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology.

Sheng X, Yan J, et al., Food and Function, 2017. 

11. Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-Induced liver damage and mortality by stimulation of innate immune cells.

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12. Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota.

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13 Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus

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14 Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice.

Ko SK, Jin M, Pyo MY, Journal of Ethnopharmocology, 2011. 

15 Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum.

Lin ZB, Journal of Pharmacological Sciences, 2005.

16 Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer.

Chen X, Hu ZP, et al., International Immunopharmacology, 2006. 

17 Effect of Ganoderma lucidum capsules on T lymphocyte subsets in football players on “living high-training low”

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18 The effects of two different ganoderma species (Lingzhi) on gene expression in human monocytic THP-1 cells.

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19 Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients.

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20 Natural killer cells: In health and disease.

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21 The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study.

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22 In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus.

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23 Pathology, Inflammation.

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24 Diabetes mellitus and inflammation.

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25 The inflammation theory of disease: The growing realization that chronic inflammation is crucial in many diseases opens new avenues for treatment.

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26 Composition and antioxidant activity of water-soluble oligosaccharides from Hericium erinaceus.

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27 Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities.

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28 Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

Han ZH, Ye JM, Wang GF, International Journal of Biological Macromolecules, 2013.

29 Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.

Qin M, Geng Y, et al., International Journal of Medicinal Mushrooms, 2016.

30 Anti-Inflammatory Effects of Inonotus obliquus in Colitis Induced by Dextran Sodium Sulfate

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31 Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice.

Mishra SK, Kang JH, et al., Journal of Ethnopharmacology, 2012. 

32 Chronic diseases, inflammation, and spices: how are they linked?

Kunnumakkara AB, Sailo BL, et al., Journal of Translational Medicine, 2018. 

33 Antioxidant potential of spices and their active constituents.

Srinivasan K, Critical Reviews in Food Science and Nutrition, 2014. 

34 Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress.

Vijayakumar RS, Surya D, Nalini N, Redox Report, 2004. 

35 Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.

Bang JS, Oh DH, et al., Arthritis Research and Therapy, 2009. 

36 Piperine ameliorates oxidative stress, inflammation and histological outcome in collagen induced arthritis.

Umar S, Golam-Sarwar AH, et al., Cellular Immunology, 2013. 

37 Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model.

Kim SH, Lee YC, Journal of Pharmacy and Pharmacology, 2009. 

38 Antiallergic effect of piperine on ovalbumin-induced allergic rhinitis in mice.

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39 Edible mushrooms: Role in the prevention of cardiovascular diseases

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40 Vitamin D and sterol composition of 10 types of mushrooms from retail suppliers in the United States.

Phillips KM, Ruggio DM, et al., Journal of Agricultural and Food Chemistry, 2011. 

41 Determination of Glucan Contents in the Fruiting Bodies and Mycelia of Lentinula edodes Cultivars.

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42 Effect of the Inonotus Obliquus Polysaccharides on Blood Lipid Metabolism and Oxidative Stress of Rats Fed High-Fat Diet In Vivo

Liang L, Zhang Z, et al., IEEE, 2009. 

43 Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice.

Sun JE, Ao ZH, et al., Journal of Ethnopharmacology, 2008. 

44 Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice and potential mechanism via PI3K-Akt signal pathway.

Wang J, Wang C, et al., Biomedicine and Pharmacotherapy, 2017. 

45 Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats

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46 Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet.

Hiwatashi K, Kosaka Y, et al., Bioscience, Biotechnology and Biochemistry, 2010. 

47 Effect of Dietary Maitake (Grifola frondosa) Mushrooms on Plasma Cholesterol and Hepatic Gene Expression in Cholesterol-Fed Mice

Sato M, Tokuji Y, et al., Journal of Oleo Science, 2013. 

48 Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters.

Agbor GA, Akinfiresoye L, et al., Food Chemistry, 2012. 

49 Black pepper and piperine reduce cholesterol uptake and enhance translocation of cholesterol transporter proteins.

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50 Effects of Piper nigrum extracts: Restorative perspectives of high-fat diet-induced changes on lipid profile, body composition, and hormones in Sprague-Dawley rats.

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51 Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats.

Kabir Y, Yamaguchi M, Kimura S, Journal of Nutritional Science and Vitaminology, 1987.

52 Lentinus edodes promotes fat removal in hypercholesterolemic mice

Yang H, Hwang I, et al., Experimental and Therapeutic Medicine, 2013. 

53 Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion’s mane mushroom).

Rahman MA, Abdullah N, Aminudin N, Biomedical Research International, 2014

54 Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.

Mori K, Kikuchi H, et al., Phytomedicine: International Journal of Phytotherapy and Phytopharmacology, 2010. 

55 Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function.

Chen YH, Lee CH, et al., International Journal of Medicinal Mushrooms, 2015. 

56 Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice.

Wang C, Chen Z, et al., Food and Chemical Toxicology, 2017. 

57 Hypoglycemic Effects of Fermented Chaga Mushroom (Inonotus obliquus) in the Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rat  

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58 Protective Effect of Polysaccharides from Inonotus obliquus on Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats

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59 Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review.

He X, Wang X, et al., International Journal of Biological Macromolecules, 2017. 

60 Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats.

Liang B, Guo Z, et al., BMC Complementary and Alternative Medicine, 2013. 

61 Antidiabetic and antioxidant activities of eight medicinal mushroom species from China.

Wu T, Xu B, International Journal of Medicinal Mushrooms, 2015. 

62 Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rats. 

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63 Piperine lowers the serum concentrations of thyroid hormones, glucose and hepatic 5’D activity in adult male mice.

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64 Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists.

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65 Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice.

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66 Improvement in insulin resistance and favourable changes in plasma inflammatory adipokines after weight loss associated with two months’ consumption of a combination of bioactive food ingredients in overweight subjects.

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67 Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle.

Maeda A, Shirao T, et al., Molecular Nutrition and Food Research, 2018.

68 Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus.

Liu JH, Li L, et al., Journal of Ethnopharmacology, 2016. 

69 Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes).

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70 Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals.

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71 In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes).

Shang X, Tan Q, et al., International Journal of Medicinal Mushrooms, 2013. 

72 Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats.

Wong JY, Abdulla MA, et al., Evidence-Based Complementary and Alternative Medicine, 2013. 

73 Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.

Qin M, Geng Y, et al., International Journal of Medicinal Mushrooms, 2016. 

74 Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota.

Diling C, Xin Y, et al., Oncotarget, 2017. 

75 Polysaccharide of Hericium erinaceus attenuates colitis in C57BL/6 mice via regulation of oxidative stress, inflammation-related signaling pathways and modulating the composition of the gut microbiota.

Ren Y, Geng Y, et al., Journal of Nutritional Biochemistry, 2018. 

76 Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study.

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77 Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway

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78 Effect of Ginsenosides on Glucose Uptake in Human Caco-2 Cells Is Mediated through Altered Na+/Glucose Cotransporter 1 Expression.

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79 A gut microbial metabolite of ginsenosides, compound K, induces intestinal glucose absorption and Na+/glucose cotransporter 1 gene expression through activation of cAMP response element binding protein.

Wang CW, Huang YC, et al., Molecular Nutrition & Food Research and Scientific Reports, 2015

80 Ganoderma lucidum (Reishi mushroom) for cancer treatment.

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81 Ganoderma lucidum (“Lingzhi”), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study.

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82 Reishi Mushroom

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